Modulation of bacterial Type III secretion system by a spermidine transporter dependent signaling pathway.
BACKGROUND: Many gram-negative bacterial pathogens employ Type III secretion systems (T3SS) to inject effector proteins into host cells in infectious processes.METHODOLOGY/PRINCIPAL FINDINGS: By screening a transposon mutant library of P.aeruginosa, we found that mutation of spuDEFGH, which encode a major spermidine uptake system, abolished the exp